acid phenol Search Results


mycophenolic acid glucuronide  (Toronto Research Chemicals)
91
Toronto Research Chemicals mycophenolic acid glucuronide
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Mycophenolic Acid Glucuronide, supplied by Toronto Research Chemicals, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phenol chloroform extraction method  (Valiant Co Ltd)
95
Valiant Co Ltd phenol chloroform extraction method
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Phenol Chloroform Extraction Method, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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synthesis  (Chem Impex International)
95
Chem Impex International synthesis
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Synthesis, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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p propargyloxyl l phenylalanine  (Chem Impex International)
95
Chem Impex International p propargyloxyl l phenylalanine
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
P Propargyloxyl L Phenylalanine, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cas  (Enamine Ltd)
99
Enamine Ltd cas
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Cas, supplied by Enamine Ltd, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cas - by Bioz Stars, 2026-07
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carboxyphenol ba  (Chem Impex International)
95
Chem Impex International carboxyphenol ba
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Carboxyphenol Ba, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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tryptophan trp  (Chem Impex International)
95
Chem Impex International tryptophan trp
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Tryptophan Trp, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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eugenol  (ChromaDex)
90
ChromaDex eugenol
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Eugenol, supplied by ChromaDex, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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eugenol - by Bioz Stars, 2026-07
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phenol  (LGC Standards)
91
LGC Standards phenol
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Phenol, supplied by LGC Standards, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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phenol - by Bioz Stars, 2026-07
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salicylic acid  (LGC Standards)
91
LGC Standards salicylic acid
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Salicylic Acid, supplied by LGC Standards, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hydroxyphenyl propionic acid  (Chem Impex International)
95
Chem Impex International hydroxyphenyl propionic acid
Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 <t>(mycophenolic</t> acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.
Hydroxyphenyl Propionic Acid, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 (mycophenolic acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.

Journal: Journal of clinical pharmacology

Article Title: Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes.

doi: 10.1002/jcph.1493

Figure Lengend Snippet: Figure 3. Age-related changes in glucuronidation activity of 10 major hepatic UGT isoforms in HLMs from neonates to elderly donors. A panel of 18 selective UGT substrates was used to assess the microsomal glucuronidation activity of UGT1A1 (estradiol [3-glucuronide], raltegravir, and dolutegravir) (A),UGT1A3 (chenodeoxycholic acid) (B),UGT1A4 (trifluoperazine and lamotrigine) (C),UGT1A6 (5-hydroxytryptophol) (D),UGT1A9 (propofol) (E), UGT1A9/2B7 (mycophenolic acid) (F), UGT2B4 (gemfibrozil) (G), UGT2B7 (zidovudine, ketopofen, valproic acid, morphine [3- and 6- glucuronides] and estradiol [17-glucuronide]) (H),UGT2B10 (amitriptyline) (I),UGT2B15 (oxazepam [S-glucuronide] and lorazepam) (J),and UGT2B17 (testosterone) (K). Symbols represent individual fraction of relative adult UGT activity (mean ± SD of 3 in vitro incubations). Solid red line represents the best fit of data using a sigmoid equation (C, F, and K) or 1-phase decay equation (A, B, D, E, G, H, I, and J). *Incubation of gemfibrozil with 60 µM atractylenolide I, used as an UGT2B7 inhibitor.

Article Snippet: Raltegravir, valproic acid, morphine, lorazepam, β-estradiol-3-glucuronide, β-estradiol-17-glucuronide, raltegravir-glucuronide, dolutegravir-glucuronide, chenodeoxycholic acid-glucuronide, trifluoperazineglucuronide, propofol-glucuronide, gemfibrozilglucuronide, mycophenolic acid-glucuronide, zidovudine-glucuronide, ketoprofen-glucuronide, valproic acid-glucuronide, morphine-3-glucuronide, morphine-6-glucuronide, gemfibrozil-glucuronide, and amitriptyline-glucuronide were purchased from Toronto Research Chemicals (Toronto, Ontario, Canada).

Techniques: Activity Assay, In Vitro, Incubation